Malignant Transformation of Cells Derived from Mouse Prostate by Epoxides and Other Derivatives of Polycyclic Hydrocarbons1
نویسندگان
چکیده
K-region epoxides of benz[a] anthracene, dibenz[a,h] anthracene, and 3-methylcholanthrene have been found to be toxic and more active in producing malignant transformation of cells derived from mouse prostate than their respective parent hydrocarbons and K-region dihydrodiols and phenols. The data support the view that metabolism of these polycyclic hydrocarbons is a prerequisite for their biological activity. 7-Bromomethylbenz [a] anthracene, the K-region epoxide of 7-methylbenz[a] anthracene, and 7-bromomethyl-12-methylbenz [a] anthracene were either inactive or less active in producing malignant transformation than the parent compounds, 7-methylbenz[a] anthracene and 7,12-dimethylbenz [a] anthracene. The 8,9-epoxide (non-K-region) of benz[a] anthracene was much less active than the K-region epoxide of this hydrocarbon; and the K-region epoxides of the noncarcinogenic hydrocarbons, phenanthrene and chrysene did not transform the cells.
منابع مشابه
Malignant transformation of cells derived from mouse prostate by epoxides and other derivatives of polycyclic hydrocarbons.
K-region epoxides of benz[a] anthracene, dibenz[a,h] anthracene, and 3-methylcholanthrene have been found to be toxic and more active in producing malignant transformation of cells derived from mouse prostate than their respective parent hydrocarbons and K-region dihydrodiols and phenols. The data support the view that metabolism of these polycyclic hydrocarbons is a prerequisite for their biol...
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